Simultaneous administration: Influenza vaccines can be administered with other vaccines, including COVID-19 vaccines. For vaccines with non-aluminum adjuvants, administration at separate anatomic sites is recommended if given concomitantly.
Travelers: Specific recommendations are provided for travelers to reduce influenza risk.
Storage and handling: Proper temperature requirements and handling procedures are crucial for maintaining vaccine efficacy.
Influenza vaccination impact was substantial. In 2017-2018, vaccination prevented an estimated 7.1 million illnesses, 3.7 million medical visits, 109,000 hospitalizations, and 8,000 deaths, despite 38% effectiveness. Vaccination during pregnancy reduced influenza risk in pregnant/postpartum women and infants <6 months. A meta-analysis found declining effectiveness 4-6 months post-vaccination, with infection odds increasing 9-28% per month overall and 12-29% per month in those ≥65 years.
Enhanced vaccines have improved efficacy in older adults compared to standard-dose in some studies. Extensive data have not shown associations between maternal influenza vaccination and adverse pregnancy outcomes. Severe allergic reactions, while rare, can occur regardless of allergy history. Emergency protocols should be in place at all vaccine administration sites.
Reference:
Grohskopf LA, Ferdinands JM, Blanton LH, Broder KR, Loehr J. Prevention and Control of Seasonal Influenza with Vaccines: Recommendations of the Advisory Committee on Immunization Practices — United States, 2024–25 Influenza Season. MMWR Recomm Rep 2024;73(No. RR-5):1–25. DOI: http://dx.doi.org/10.15585/mmwr.rr7305a1.