Thanks to Mary Jane Francis
From a death notice about a man named Shumway: “At the time of his death, he had a framed New Yorker cartoon in his room that said ‘My desire to be well-informed is currently at odds with my desire to remain sane.’”
ChatGPT chimes in: it is not actually a New Yorker cartoon, although it is very often attributed to The New Yorker.
The cartoon is by David Sipress. Sipress says he drew it in the 1990s, probably during the Bosnia crisis. He has said he doesn’t remember where it was first published. It subsequently became enormously popular and was repeatedly reproduced and attributed to The New Yorker.